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© IRL Press Limited

The elucidation of protein function from its amino acid sequence

T. C. Hodgman

M.R.C. Laboratory of Molecular Biology Hill's Road, Cambridge CB2 2QH, UK

This review gives an outline of how computers may be used to determine the function of a protein, when only its primary structure is known. The current programming methods are outlined in general terms before their detailed application is discussed, and the common ways of predicting protein structure are also introduced. Identification is usually by database searching and sequence alignment, though a collection of motifs relating sequence to function are also described.


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