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© IRL Press Limited

METAMOD: software for steady-state modelling and control analysis of metabolic pathways on the BBC microcomputer

J. H. S. Hofmeyr * and K. J. van der Merwe

Department of Biochemisty, University of Stellenbosch Stellenbosch 7600, South Africa

*To whom reprint requests should be sent

METAMOD, a BBC microcomputer-based software package for steady-state modelling and control analysis of model metabolic pathways, is described, The package consists of two programs. METADEF allows the user to define the pathway in terms of reactions, rate equations and initial concentrations of metabolites. METACAL uses one of two algorithms to calculate the steady-state concentrations and fluxes. One algorithm uses the current ratio of production and consumption rates of variable metabolites to adjust iteratively their concentrations in such a way that they converge towards the steady state. The other algorithm solves the roots of the system equations by means of a quasi-Newtonian procedure. Control analysis allows the calculation of elasticity, control and response coefficients, by means of finite difference approximation. METAMOD is interactive and easy to use, and suitable for teaching and research purposes.

Received on January 17, 1986; accepted on June 2, 1986

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