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© IRL Press Limited

A demonstration of pharmacokinetics and physiological modelling using a microcomputer for data capture and analysis

L. Kirkup , D. J. Nichols 1,* and J. Sutherland 2

Physics Department, Paisley College of Technology Paisley, PA1 2BE
1Physics Department and Biology Department, Paisley College of Technology Paisley, PA1 2BE
2Scottish Council for Educational Technology Victoria Crescent, Glasgow, G12 9JN, Scotlan

*To whom reprint requests should be sent

We describe a simple and inexpensive demonstration of mass transport and exchange using dye clearance from a hydro-dynamic model. A microcomputer was used for data acquisition and storage, non-linear least squares curve fitting, compartmental analysis and parameter estimation. The system is useful for demonstrating the indicator — dilution technique for fluid volume measurement and compartmental analysis in pharmacokinetics.

Received on August 8, 1986; accepted on September 25, 1986

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