Skip Navigation


Bioinformatics Advance Access originally published online on March 22, 2004
This Article
Right arrow FREE Full Text (Print PDF) Freely available
Right arrow FREE Full Text (Screen PDF)
Right arrow Supplementary data
Right arrow All Versions of this Article:
20/12/1966    most recent
bth168v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Voigt, C.
Right arrow Articles by Serrano-Fernández, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Voigt, C.
Right arrow Articles by Serrano-Fernández, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Bioinformatics 20(12) © Oxford University Press 2004; all rights reserved.

Applications Note

Non-linear conversion between genetic and physical chromosomal distances

Claudia Voigt , Steffen Möller , Saleh M. Ibrahim and Pablo Serrano-Fernández *

Proteome Center Rostock, Joachim-Jungius-Strasse 9, 18059 Rostock, Germany

Received on January 29, 2004; accepted on March 8, 2004
Advance Access Publication March 22, 2004

Summary: A supervised nonlinear interpolation significantly improves the reliability of conversions from genetic distances to physical distances as compared with the linear ones. A webaccessible application was created that addresses this question with a graphical presentation that may be wrapped by local installations.

Motivation: Genetic linkage maps and radiation hybrid (RH) maps are based on the rate of uncoupling between linked genetic markers. These are usually measured in centiMorgan (cM) when uncoupling is originated by natural recombination or in centiRay (cR) for chromosomes that are irradiated artificially to separate the markers. Physical maps arise from genome-wide DNA sequencing and are measured in bp.

This work was originally motivated as an extension of the software application Expressionview (Fischer et al., 2003), exploring its spectrum of appliance combining different mapping systems. The relationship between physical and genetic maps is known to be not always linear (Yu et al., 2001). The shift from the linear model seems to depend on local idiosyncrasies of the chromosomes and the kind of genetic map used. The present application addresses this problem for the first time.

Availability: http://qtl.pzr.uni-rostock.de/cartographer.php

Contact: serrano{at}pzr.uni-rostock.de

* To whom correspondence should be addressed.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BioinformaticsHome page
C. Rezvoy, D. Charif, L. Gueguen, and G. A.B. Marais
MareyMap: an R-based tool with graphical interface for estimating recombination rates
Bioinformatics, August 15, 2007; 23(16): 2188 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 Brief BioinformHome page
E. Merelli, G. Armano, N. Cannata, F. Corradini, M. d'Inverno, A. Doms, P. Lord, A. Martin, L. Milanesi, S. Moller, et al.
Agents in bioinformatics, computational and systems biology
Brief Bioinform, January 1, 2007; 8(1): 45 - 59.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
P. Serrano-Fernandez, S. M. Ibrahim, D. Koczan, U. K. Zettl, and S. Moller
In silico fine-mapping: narrowing disease-associated loci by intergenomics
Bioinformatics, April 15, 2005; 21(8): 1737 - 1738.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.