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Bioinformatics Advance Access originally published online on March 25, 2004
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Bioinformatics 20(12) © Oxford University Press 2004; all rights reserved.

Applications Note

A genetic algorithm for the detection of new cis-regulatory modules in sets of coregulated genes

Stein Aerts *, Peter Van Loo , Yves Moreau and Bart De Moor

Department of Electrical Engineering (ESAT-SCD), Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Heverlee (Leuven), Belgium

Received on August 7, 2003; revised on December 30, 2004; accepted on January 29, 2004
Advance Access Publication March 25, 2004

Summary: The implementation of a genetic algorithm is described that provides a fast method of searching for the optimal combination of transcription factor binding sites in a set of regulatory sequences.

Availability: The algorithm can be used transparently as a web service from within the Toucan software. Toucan can be accessed at http://www.esat.kuleuven.ac.be/~saerts/software/toucan.php. A standalone version of the software is available upon request.

Contact: stein.aerts{at}esat.kuleuven.ac.be

* To whom correspondence should be addressed.


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