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Bioinformatics Advance Access originally published online on March 25, 2004
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Bioinformatics 20(12) © Oxford University Press 2004; all rights reserved.

Applications Note

ConSSeq: a web-based application for analysis of amino acid conservation based on HSSP database and within context of structure

R. H. Higa 1, A. J. Montagner 1, R. C. Togawa 2, P. R. Kuser 1, M. E. B. Yamagishi 1, A. L. Mancini 1, G. Pappas, Jr. 3, R. T. Miura 2, L. G. Horita 2 and G. Neshich 1,*

1 Núcleo de Bioinformática, Centro Nacional de Pesquisa Agropecuária, Empresa Brasileira de Pesquisa Agropecuária, Campinas, SP, Brazil, 2 Laboratório de Bioinformática, Embrapa/Recursos Genéticos e Biotecnologia and 3 Laboratório de Bioinformática, Universidade Católica de Brasília, DF-70770-9001, Brasilia

Received on September 2, 2003; revised on January 24, 2004; accepted on February 1, 2004
Advance Access Publication March 25, 2004

Summary: A web-based application to analyze protein amino acids conservation—Consensus Sequence (ConSSeq) is presented. ConSSeq graphically represents information about amino acid conservation based on sequence alignments reported in homology-derived structures of proteins. Beyond the relative entropy for each position in the alignment, ConSSeq also presents the consensus sequence and information about the amino acids, which are predominant at each position of the alignment. ConSSeq is part of the STING Millennium Suite and is implemented as a Java Applet.

Availability: http://sms.cbi.cnptia.embrapa.br/SMS/STINGm/consseq/, http://trantor.bioc.columbia.edu/SMS/STINGm/consseq/, http://mirrors.rcsb.org//SMS/STINGm/consseq/, http://www.es.embnet.org/SMS/STINGm/consseq/ and http://www.ar.embnet.org/SMS/STINGm/consseq/

Contact: neshich{at}cbi.cnptia.embrapa.br

* To whom correspondence should be addressed.


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