Bioinformatics Advance Access originally published online on April 29, 2004
Bioinformatics 2004 20(15):2466-2470; doi:10.1093/bioinformatics/bth253
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Bioinformatics 20(15) © Oxford University Press 2004; all rights reserved.
Applications Note |
HPID: The Human Protein Interaction Database
1 School of Computer Science and Engineering, Inha University, Inchon 402-751, Korea and 2 Biomatics Laboratory, Department of Biosystems, KAIST, Daejeon 305-701, Korea
Received on November 17, 2003; revised on February 9, 2004; accepted on March 17, 2004
Advance Access Publication April 29, 2004
Summary: The Human Protein Interaction Database (http://www.hpid.org) was designed (1) to provide human protein interaction information pre-computed from existing structural and experimental data, (2) to predict potential interactions between proteins submitted by users and (3) to provide a depository for new human protein interaction data from users. Two types of interaction are available from the pre-computed data: (1) interactions at the protein superfamily level and (2) those transferred from the interactions of yeast proteins. Interactions at the superfamily level were obtained by locating known structural interactions of the PDB in the SCOP domains and identifying homologs of the domains in the human proteins. Interactions transferred from yeast proteins were obtained by identifying homologs of the yeast proteins in the human proteins. For each human protein in the database and each query submitted by users, the protein superfamilies and yeast proteins assigned to the protein are shown, along with their interacting partners. We have also developed a set of web-based programs so that users can visualize and analyze protein interaction networks in order to explore the networks further.
Availability: http://www.hpid.org
Supplementary information: http://wilab.inha.ac.kr/HPID/Statistics.htm
Contact: khan{at}inha.ac.kr
* To whom correspondence should be addressed.
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