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Bioinformatics Advance Access originally published online on April 22, 2004
Bioinformatics 2004 20(16):2836-2838; doi:10.1093/bioinformatics/bth276
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Bioinformatics vol. 20 issue 16 © Oxford University Press 2004; all rights reserved.

Applications Note

ProteoMix: an integrated and flexible system for interactively analyzing large numbers of protein sequences

Eisuke Chikayama 1, Atsushi Kurotani 1, Yutaka Kuroda 1,{dagger} and Shigeyuki Yokoyama 1,2,3,4,*

1 Protein Research Group, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan, 2 Cellular Signaling Laboratory and 3 Structurome Research Group, RIKEN Harima Institute at SPring-8, 1-1-1 Kohto, Mikazuki-cho, Sayo, Hyogo 679-5148, Japan and, 4 Department of Biophysics and Biochemistry, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Received on March 11, 2004; accepted on March 26, 2004
Advance Access Publication April 22, 2004

Summary: ProteoMix is a suite of JAVA programs for identifying, annotating and predicting regions of interest in large sets of amino acid sequences, according to systematic and consistent criteria. It is based on two concepts (1) the integration of results from different sequence analysis tools increases the prediction reliability; and (2) the integration protocol is critical and needs to be easily adaptable in a case-by-case manner. ProteoMix was designed to analyze simultaneously multiple protein sequences using several bioinformatics tools, merge the results of the analyses using logical functions and display them on an integrated viewer. In addition, new sequences can be added seamlessly to an analysis performed on an initial set of sequences. ProteoMix has a modular design, and bioinformatics tools are run on remote servers accessed using the Internet Simple Object Access Protocol (SOAP), ensuring the swift implementation of additional tools. ProteoMix has a user-friendly interactive graphical user interface environment and runs on PCs with Microsoft OS.

Availability: ProteoMix is freely available for academic users at http://bio.gsc.riken.jp/ProteoMix/.

Contact: yokoyama{at}biochem.s.u-tokyo.ac.jp

* To whom correspondence should be addressed.

{dagger} Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo 184-0012, Japan


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