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Bioinformatics Advance Access originally published online on May 6, 2004
Bioinformatics 2004 20(16):2853-2856; doi:10.1093/bioinformatics/bth296
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Bioinformatics vol. 20 issue 16 © Oxford University Press 2004; all rights reserved.

Applications Note

ASIAN: a website for network inference

Sachiyo Aburatani 1, Kousuke Goto 2, Shigeru Saito 2, Masaki Fumoto 2, Akira Imaizumi 1,3, Nobuyoshi Sugaya 1, Hiroo Murakami 1, Makihiko Sato 1,4, Hiroyuki Toh 5 and Katsuhisa Horimoto 1,*

1 Laboratory of Biostatistics, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan, 2 Bioscience Group, Infocom Corporation, Mitsui Sumitomo Insurance Surugadai Annex Building, 3-11, Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan, 3 Advanced Technology Department, Fermentation & Biotechnology Laboratories, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681, Japan, 4 Computer Science and Engineering Centre, Fujitsu Limited, 9-3, Nakase 1-chome, Mihama-ku, Chiba City, Chiba 261-8588, Japan and 5 Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan

Received on February 16, 2004; revised on April 6, 2004; accepted on April 26, 2004
Advance Access Publication May 6, 2004

Summary: We constructed a website for inferring a network by applying the graphical Gaussian model, from a large amount of data, including redundant information. The available tools on the website are based on a system, named ASIAN (Automatic System for Inferring A Network), in combination with the two methods in our previous papers, which were designed to analyze gene expression profiles on a genomic scale. One of the remarkable features of the website is its ability to infer a network, concomitant with hierarchical clustering and the following estimation of cluster boundaries.

Availability: http://eureka.ims.u-tokyo.ac.jp/asian

Contact: khorimot{at}ims.u-tokyo.ac.jp

* To whom correspondence should be addressed.


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