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Bioinformatics Advance Access originally published online on May 14, 2004
Bioinformatics 2004 20(16):2874-2877; doi:10.1093/bioinformatics/bth314
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Bioinformatics vol. 20 issue 16 © Oxford University Press 2004; all rights reserved.

Applications Note

Thermodynamics of enzyme-catalyzed reactions—a database for quantitative biochemistry

Robert N. Goldberg , Yadu B. Tewari and Talapady N. Bhat *

Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA

Received on March 16, 2004; accepted on May 4, 2004
Advance Access Publication May 14, 2004

Summary: The Thermodynamics of Enzyme-catalyzed Reactions Database (TECRDB) is a comprehensive collection of thermodynamic data on enzyme-catalyzed reactions. The data, which consist of apparent equilibrium constants and calorimetrically determined molar enthalpies of reaction, are the primary experimental results obtained from thermodynamic studies of biochemical reactions. The results from 1000 published papers containing data on 400 different enzyme-catalyzed reactions constitute the essential information in the database. The information is managed using Oracle and is available on the Web.

Availability: http://xpdb.nist.gov/enzyme_thermodynamics/

Contact: For Web and database related issues: bhat{at}nist.gov and for Scientific data, including additions and corrections: robert.goldberg{at}nist.gov

* To whom correspondence should be addressed.

Certain trade names and company products are identified in this paper to specify adequately the computer products needed to develop this data system. In no case does such identification imply endorsement by the National Institute of Standards and Technology (NIST), or does it imply that the products are necessarily the best available for the purpose.


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