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Bioinformatics Advance Access originally published online on January 22, 2004
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Bioinformatics 20(3) © Oxford University Press 2004; all rights reserved.

Applications Note

PIVOT: Protein Interacions VisualizatiOn Tool

Nir Orlev 1,*, Ron Shamir 2 and Yosef Shiloh 1

1 Department of Human Genetics, Faculty of Medicine and 2 School of Computer Science, Tel Aviv University, Israel

Received on February 26, 2003 ; revised on June 26, 2003 ; accepted on August 6, 2003
Advance Access Publication January 22, 2004

Summary: Protein Interaction VisualizatiOn Tool (PIVOT) is a visualization tool for protein–protein interactions. It allows the user to create personal data sets of interactions by combining information from private and public data sources. The user can gradually access the interactions' data using a clear interactive map that is focused on the researcher's protein of interest, and is reshaped and expanded in response to his/her queries. It also offers several visual enhancements and intelligent queries that help the user efficiently study it. PIVOT allows the user to search the interactions data set for paths connecting proteins that are expected to co-operate. The user can also employ PIVOT to predict unknown interactions among proteins, based on interactions among their homologous proteins in other species.

Availability: Freely available for academic users, at http://www.cs.tau.ac.il/~rshamir/pivot

Supplementary information: A demonstration video clip is available at http://www.cs.tau.ac.il/~rshamir/pivot/Demo.avi

Contact: niro{at}post.tau.ac.il

* To whom correspondence should be addressed.


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[Abstract] [Full Text] [PDF]


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