Bioinformatics Advance Access originally published online on February 10, 2004
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Bioinformatics 20(8) © Oxford University Press 2004; all rights reserved.
Applications Note |
ConSeq: the identification of functionally and structurally important residues in protein sequences
1 Department of Biochemistry and 2 Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978 Israel and 3 Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Received on June 10, 2003; revised on August 22, 2003; accepted on September 9, 2003
Advance Access Publication February 10, 2004
Motivation: ConSeq is a web server for the identification of biologically important residues in protein sequences. Functionally important residues that take part, e.g. in ligand binding and protein–protein interactions, are often evolutionarily conserved and are most likely to be solvent-accessible, whereas conserved residues within the protein core most probably have an important structural role in maintaining the protein's fold. Thus, estimated evolutionary rates, as well as relative solvent accessibility predictions, are assigned to each amino acid in the sequence; both are subsequently used to indicate residues that have potential structural or functional importance.
Availability: The ConSeq web server is available at http://conseq.bioinfo.tau.ac.il/
Supplementary information: The ConSeq methodology, a description of its performance in a set of five well-documented proteins, a comparison to other methods, and the outcome of its application to a set of 111 proteins of unknown function, are presented at http://conseq.bioinfo.tau.ac.il/ under ‘OVERVIEW’, ‘VALIDATION’, ‘COMPARISON’ and ‘PREDICTIONS’, respectively.
Contact: bental{at}ashtoret.tau.ac.il
* To whom correspondence should be addressed.
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