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Bioinformatics Advance Access originally published online on April 28, 2005
Bioinformatics 2005 21(13):3025-3033; doi:10.1093/bioinformatics/bti466
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

A variational Bayesian mixture modelling framework for cluster analysis of gene-expression data

Andrew E. Teschendorff *, Yanzhong Wang , Nuno L. Barbosa-Morais , James D. Brenton and Carlos Caldas

Department of Oncology, Cancer Genomics Program, Hutchison-MRC Research Centre, University of Cambridge Hills Road, Cambridge CB2 2XZ, UK

*To whom correspondence should be addressed.

Motivation: Accurate subcategorization of tumour types through gene-expression profiling requires analytical techniques that estimate the number of categories or clusters rigorously and reliably. Parametric mixture modelling provides a natural setting to address this problem.

Results: We compare a criterion for model selection that is derived from a variational Bayesian framework with a popular alternative based on the Bayesian information criterion. Using simulated data, we show that the variational Bayesian method is more accurate in finding the true number of clusters in situations that are relevant to current and future microarray studies. We also compare the two criteria using freely available tumour microarray datasets and show that the variational Bayesian method is more sensitive to capturing biologically relevant structure.

Availability: We have developed an R-package vabayelMix, available from www.cran.r-project.org, that implements the algorithm described in this paper.

Contact: aet21{at}cam.ac.uk

Supplementary information: http://bioinformatics.oxfordjournals.org


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