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Bioinformatics Advance Access originally published online on April 7, 2005
Bioinformatics 2005 21(13):3049-3050; doi:10.1093/bioinformatics/bti439
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

pFind: a novel database-searching software system for automated peptide and protein identification via tandem mass spectrometry

Dequan Li 1,2,*, Yan Fu 1,2, Ruixiang Sun 1, Charles X. Ling 3, Yonggang Wei 1, Hu Zhou 4, Rong Zeng 4, Qiang Yang 5, Simin He 1 and Wen Gao 1,2

1Institute of Computing Technology, Chinese Academy of Sciences Beijing 100080, China
2Graduate School of Chinese Academy of Sciences Beijing 100039, China
3Department of Computer Science, The University of Western Ontario Canada
4Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai 200031, China
5Department of Computer Science, Hong Kong University of Science and Technology Hong Kong, China

*To whom correspondence should be addressed.

Summary: Research in proteomics requires powerful database-searching software to automatically identify protein sequences in a complex protein mixture via tandem mass spectrometry. In this paper, we describe a novel database-searching software system called pFind (peptide/protein Finder), which employs an effective peptide-scoring algorithm that we reported earlier. The pFind server is implemented with the C++ STL, .Net and XML technologies. As a result, high speed and good usability of the software are achieved.

Availability: The pFind web server can be freely accessed through the website http://pfind.jdl.ac.cn. In this website, the compiled binary of the local version is also available.

Contact: dqli{at}jdl.ac.cn


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