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Bioinformatics Advance Access originally published online on April 26, 2005
Bioinformatics 2005 21(14):3168-3170; doi:10.1093/bioinformatics/bti453
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Association mapping and fine mapping with TreeLD

Sebastian Zöllner *, Xiaoquan Wen and Jonathan K. Pritchard

Department of Human Genetics, The University of Chicago 920 East 58th Street–CLSC 507, Chicago, IL 60637, USA

*To whom correspondence should be addressed.

Summary: The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data, based on an inferred ancestry of the sample. Fundamentally, the TreeLD approach is based on the idea that the evidence for association at a particular position is contained in the ancestral tree relating the sampled chromosomes at that position. TreeLD provides an easy-to-use interface and can be applied to case–control, TDT trio and quantitative trait data.

Availability: The program TreeLD is available on the Internet from http://pritch.bsd.uchicago.edu/software.html

Contact: szoellne{at}genetics.bsd.uchicago.edu

Received on January 31, 2005; revised on April 12, 2005; accepted on April 13, 2005

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