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Bioinformatics Advance Access originally published online on May 26, 2005
Bioinformatics 2005 21(15):3312-3313; doi:10.1093/bioinformatics/bti507
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

SECISDesign: a server to design SECIS-elements within the coding sequence

Anke Busch , Sebastian Will and Rolf Backofen *

Friedrich-Schiller-University Jena, Institute of Computer Science, Chair for Bioinformatics Ernst-Abbe-Platz 2, 07743 Jena, Germany

*To whom correspondence should be addressed.

Summary: SECISDesign is a server for the design of SECIS-elements and arbitrary RNA-elements within the coding sequence of an mRNA. The element has to satisfy both structure and sequence constraints. At the same time, a certain amino acid similarity to the original protein has to be kept. The designed sequence can be used for recombinant expression of selenoproteins in Escherichia coli.

Availability: The server is available at http://www.bio.inf.uni-jena.de/Software/SECISDesign/index.html

Contact: backofen{at}inf.uni-jena.de

Received on March 29, 2005; accepted on May 17, 2005

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