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Bioinformatics Advance Access originally published online on June 14, 2005
Bioinformatics 2005 21(16):3433-3434; doi:10.1093/bioinformatics/bti541
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content

Zsuzsanna Dosztányi *, Veronika Csizmok , Peter Tompa and István Simon

Institute of Enzymology, BRC, Hungarian Academy of Sciences PO Box 7, H-1518 Budapest, Hungary

*To whom correspondence should be addressed.

Summary: Intrinsically unstructured/disordered proteins and domains (IUPs) lack a well-defined three-dimensional structure under native conditions. The IUPred server presents a novel algorithm for predicting such regions from amino acid sequences by estimating their total pairwise interresidue interaction energy, based on the assumption that IUP sequences do not fold due to their inability to form sufficient stabilizing interresidue interactions. Optional to the prediction are built-in parameter sets optimized for predicting short or long disordered regions and structured domains.

Availability: The IUPred server is available for academic users at http://iupred.enzim.hu

Contact: zsuzsa{at}enzim.hu

Received on March 24, 2005; revised on May 27, 2005; accepted on June 13, 2005

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