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Bioinformatics 2005 21(16):3439-3440; doi:10.1093/bioinformatics/bti525
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis

Steffen Durinck 1,2,*, Yves Moreau 1, Arek Kasprzyk 2, Sean Davis 3, Bart De Moor 1, Alvis Brazma 2 and Wolfgang Huber 2

1Department of Electronical Engineering ESAT-SCD, K.U.Leuven, Kasteelpark Arenberg 10, 3001 Leuven-Heverlee, Belgium
2EBI, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK
3Cancer Genetics Branch, National Human Genome Research Institute, National Institute of Health 50 South Drive, Bethesda, MD 20892-8000, USA

*To whom correspondence should be addressed.

Summary: biomaRt is a new Bioconductor package that integrates BioMart data resources with data analysis software in Bioconductor. It can annotate a wide range of gene or gene product identifiers (e.g. Entrez-Gene and Affymetrix probe identifiers) with information such as gene symbol, chromosomal coordinates, Gene Ontology and OMIM annotation. Furthermore biomaRt enables retrieval of genomic sequences and single nucleotide polymorphism information, which can be used in data analysis. Fast and up-to-date data retrieval is possible as the package executes direct SQL queries to the BioMart databases (e.g. Ensembl). The biomaRt package provides a tight integration of large, public or locally installed BioMart databases with data analysis in Bioconductor creating a powerful environment for biological data mining.

Availability: http://www.bioconductor.org. LGPL

Contact: steffen.durinck{at}esat.kuleuven.ac.be

Received on April 12, 2005; revised on May 25, 2005; accepted on May 31, 2005

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