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Bioinformatics Advance Access originally published online on June 30, 2005
Bioinformatics 2005 21(17):3568-3569; doi:10.1093/bioinformatics/bti563
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Published by Oxford University Press 2005

TICO: a tool for improving predictions of prokaryotic translation initiation sites

Maike Tech *, Nico Pfeifer , Burkhard Morgenstern and Peter Meinicke

Abteilung Bioinformatik, Institut für Mikrobiologie und Genetik, Georg-August-Universität Göttingen Goldschmidtstrasse 1, 37077 Göttingen, Germany

*To whom correspondence should be addressed.

Summary: We provide the tool ‘TICO’ (Translation Initiation site COrrection) for improving the results of conventional gene finders for prokaryotic genomes with regard to exact localization of the translation initiation site (TIS). At the current state TICO provides an interface for direct post processing of the predictions obtained from the widely used program GLIMMER. Our program is based on a clustering algorithm for completely unsupervised scoring of potential TIS locations.

Availability: Our tool can be freely accessed through a web interface at http://tico.gobics.de/

Contact: maike{at}gobics.de


Received on May 9, 2005; revised on June 24, 2005; accepted on June 27, 2005

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M. Tech, B. Morgenstern, and P. Meinicke
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