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Bioinformatics Advance Access originally published online on August 2, 2005
Bioinformatics 2005 21(18):3669-3671; doi:10.1093/bioinformatics/bti606
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GenColors: accelerated comparative analysis and annotation of prokaryotic genomes at various stages of completeness

Alessandro Romualdi 1, Roman Siddiqui 2, Gernot Glöckner 2, Rüdiger Lehmann 2 and Jürgen Sühnel 1,*

1Biocomputing Group, Institute of Molecular Biotechnology Beutenbergstrasse 11, 07745 Jena, Germany
2Genome Analysis, Institute of Molecular Biotechnology Beutenbergstrasse 11, 07745 Jena, Germany

*To whom correspondence should be addressed.

Summary: GenColors is a new web-based software/database system aimed at an improved and accelerated annotation of prokaryotic genomes, considering information on related genomes and making extensive use of genome comparison. It offers a seamless integration of data from ongoing sequencing projects and annotated genomic sequences obtained from GenBank. The genome comparison tools determine, for example, best-bidirectional hits, gene conservation, syntenies and gene core sets. Swiss-Prot/TrEMBL hits allow annotations in an effective manner. To further support the annotation base-specific quality data can also be displayed if available. With GenColors dedicated genome browsers containing a group of related genomes can be easily set up and maintained. It has been efficiently used for Borrelia garinii and is currently applied to various ongoing genome projects.

Availability: Detailed information on GenColors is available at http://gencolors.imb-jena.de. Online usage of GenColors-based genome browsers is the preferred application mode. The system is also available upon request for local installation.

Contact: jsuehnel{at}imb-jena.de

Received on February 22, 2005; revised on May 10, 2005; accepted on July 28, 2005

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