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Bioinformatics Advance Access originally published online on September 27, 2005
Bioinformatics 2005 21(23):4315-4316; doi:10.1093/bioinformatics/bti693
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oxfordjournals.org
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MACiE: a database of enzyme reaction mechanisms

Gemma L. Holliday 1, Gail J. Bartlett 2,{dagger}, Daniel E. Almonacid 1, Noel M. O'Boyle 1, Peter Murray-Rust 1, Janet M. Thornton 2 and John B. O. Mitchell 1,*

1Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge Lensfield Road, Cambridge, CB2 1EW, UK
2EMBL-EBI Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

*To whom correspondence should be addressed.

Summary: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create a classification system which reflects the actual chemical mechanism (catalytic steps) of an enzyme reaction, not only the overall reaction.

Availability: http://www-mitchell.ch.cam.ac.uk/macie/

Contact: jbom1{at}cam.ac.uk

Received on July 21, 2005; revised on September 22, 2005; accepted on September 23, 2005

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