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Bioinformatics Advance Access originally published online on November 5, 2004
Bioinformatics 2005 21(6):835-836; doi:10.1093/bioinformatics/bti119
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© The Author 2004. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

OMGProm: a database of orthologous mammalian gene promoters

Saranyan K. Palaniswamy , Victor X. Jin , Hao Sun and Ramana V. Davuluri *

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University Columbus, OH 43210, USA

*To whom correspondence should be addressed.

Summary: Sequence comparisons between human and rodents are increasingly being used for the identification of gene regulatory regions. The effectiveness of such an approach largely depends on the quality and availability of promoter sequences. We developed OMGProm by integrating three data sources: (1) experimentally supported full-length cDNA, promoter and first exon sequences; (2) homology information from HomoloGene and (3) the human and mouse genomic sequences. The current version of OMGProm contains 8550 promoter pairs of 6373 orthologous human and mouse genes, where supporting experimental evidence for transcription start site annotation exists in at least one species.

Availability: OMGProm can be accessed from http://bioinformatics.med.ohio-state.edu/OMGProm

Contact: davuluri-1{at}medctr.osu.edu

Supplementary information: Additional information on methods and implementation is available at http://bioinformatics.med.ohio-state.edu/OMGProm/si.jsp.


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