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Bioinformatics 2005 21(Suppl 2):ii222-ii223; doi:10.1093/bioinformatics/bti1136
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oxfordjournals.org

Horizontal gene transfer depends on gene content of the host

Csaba Pál 1,2, Balázs Papp 3 and Martin J. Lercher 1,4,*

1European Molecular Biology Laboratory 69012 Heidelberg, Germany
2MTA, Eötvös Loránd University Budapest H-1117, Hungary
3School of Biological Sciences, University of Manchester Manchester M13 9PT, UK
4Department of Biology and Biochemistry, University of Bath Bath BA2 7AY, UK

*To whom correspondence should be addressed.

Horizontal gene transfer is a major contributor to the evolution of bacterial genomes. We examine this process through a combination of comparative genomics and in silico analysis of the Escherichia coli metabolic network. We validate our horizontal transfer estimates by confirming the predicted gradual amelioration of GC content over time. We find that the chance of acquiring a gene by horizontal transfer is up to six times higher if an enzyme that catalyses a coupled metabolite flux is already encoded in the host genome.

Contact: Lercher{at}embl.de


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