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Bioinformatics Advance Access originally published online on April 4, 2006
Bioinformatics 2006 22(11):1402-1403; doi:10.1093/bioinformatics/btl131
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

ALTree: association detection and localization of susceptibility sites using haplotype phylogenetic trees

Claire Bardel 1,*, Vincent Danjean 2 and Emmanuelle Génin 1

1 Unité de recherche en Génétique Épidémiologique et Structure des Populations Humaines, INSERM U535 Villejuif, France
2 Laboratoire ID-IMAG, UMR 5132 Grenoble, France

*To whom correspondence should be addressed.

Summary: Finding the genes involved in complex diseases susceptibility and among those genes, localizing the variant sites explaining this susceptibility is a major goal of genetic epidemiology. In this context, haplotypic methods that use the joint information on several markers may be of particular interest. When the number of haplotypes is large, a grouping may be required. Phylogenetic trees allow such groupings of haplotypes based on their evolutionary history and may help in the detection and localization of disease susceptibility sites. In this paper, we present a new software to perform phylogeny-based association and localization analysis.

Availability: The software package, including all documentation and example files, is freely available at http://claire.bardel.free.fr/software.html. It is distributed under the GPL license.

Contact: bardel{at}vjf.inserm.fr

Received on January 13, 2006; revised on March 17, 2006; accepted on March 31, 2006

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