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Bioinformatics Advance Access originally published online on April 13, 2006
Bioinformatics 2006 22(12):1532-1533; doi:10.1093/bioinformatics/btl143
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
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FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster

Boris Adryan * and Sarah A. Teichmann

MRC Laboratory of Molecular Biology Cambridge CB2 2QH, UK

*To whom correspondence should be addressed.

Summary: We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.

Availability: http://www.flytf.org/

Contact: boris{at}mrc-lmb.cam.ac.uk

Supplementary information: Supplementary data are available at http://www.flytf.org/

Received on March 6, 2006; revised on March 28, 2006; accepted on April 10, 2006

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