Bioinformatics Advance Access originally published online on July 28, 2006
Bioinformatics 2006 22(20):2574-2576; doi:10.1093/bioinformatics/btl413
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Hierarchical classification of hydrolases catalytic sites
School of Enzymology, Department of Chemistry, M.V. Lomonosov Moscow State University Moscow, 119992, Russia
*To whom correspondence should be addressed.
Summary: Universal ontology of catalytic sites is required to systematize enzyme catalytic sites, their evolution as well as relations between catalytic sites and protein families, organisms and chemical reactions. Here we present a classification of hydrolases catalytic sites based on hierarchical organization. The web-accessible database provides information on the catalytic sites, protein folds, EC numbers and source organisms of the enzymes and includes software allowing for analysis and visualization of the relations between them.
Availability: http://www.enzyme.chem.msu.ru/hcs/
Contact: gariev{at}hotmail.com
Received on March 13, 2006; revised on July 7, 2006; accepted on July 25, 2006