Skip Navigation


Bioinformatics Advance Access originally published online on September 5, 2006
Bioinformatics 2006 22(22):2711-2714; doi:10.1093/bioinformatics/btl468
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (Print PDF) Freely available
Right arrow Supplementary Data
Right arrowOA All Versions of this Article:
22/22/2711    most recent
btl468v1
Right arrow Comments: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Comments are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Google Scholar
Right arrow Articles by Dlakic, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dlakic, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold

Mensur Dlakic

Department of Microbiology, Montana State University Bozeman, MT 59717, USA

Two RNases, Dicer and Argonaute, are at the heart of the RNA interference (RNAi) molecular machinery responsible for gene silencing. Both RNases contain multiple domains, most of which have been characterized or have functions that can be predicted based on sequence comparisons. However, Dicers of higher eukaryotes contain the domain known as DUF283 which at present has no assigned role. Using sensitive profile–profile comparisons, we detected a divergent double-stranded RNA-binding domain coinciding with the DUF283 of Dicer. This finding has potential implications regarding the mechanistic role of Dicer in RNAi.

Contact: mdlakic{at}montana.edu

Supplementary information: Supplementary images are available at Bioinformatics online.

Received on June 14, 2006; revised on August 7, 2006; accepted on August 29, 2006

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
D. Wichadakul, S. Numnark, and S. Ingsriswang
d-Omix: a mixer of generic protein domain analysis tools
Nucleic Acids Res., July 1, 2009; 37(suppl_2): W417 - W421.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
D. de Jong, M. Eitel, W. Jakob, H.-J. Osigus, H. Hadrys, R. DeSalle, and B. Schierwater
Multiple Dicer Genes in the Early-Diverging Metazoa
Mol. Biol. Evol., June 1, 2009; 26(6): 1333 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
E. V. Dolgosheina, R. D. Morin, G. Aksay, S. C. Sahinalp, V. Magrini, E. R. Mardis, J. Mattsson, and P. J. Unrau
Conifers have a unique small RNA silencing signature
RNA, August 1, 2008; 14(8): 1508 - 1515.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. A. Casas-Mollano, J. Rohr, E.-J. Kim, E. Balassa, K. van Dijk, and H. Cerutti
Diversification of the Core RNA Interference Machinery in Chlamydomonas reinhardtii and the Role of DCL1 in Transposon Silencing
Genetics, May 1, 2008; 179(1): 69 - 81.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Ye, Z. Paroo, and Q. Liu
Functional Anatomy of the Drosophila MicroRNA-generating Enzyme
J. Biol. Chem., September 28, 2007; 282(39): 28373 - 28378.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.