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Bioinformatics Advance Access originally published online on September 11, 2006
Bioinformatics 2006 22(22):2835-2837; doi:10.1093/bioinformatics/btl471
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

SPEED: a molecular-evolution-based database of mammalian orthologous groups

Eric J. Vallender 1, Justin E. Paschall 2, Christine M. Malcom 1,3, Bruce T. Lahn 1 and Gerald J. Wyckoff 2,*

1 Department of Human Genetics and Committee on Genetics, Howard Hughes Medical Institute, University of Chicago 920 East 58th Street, Chicago, IL 60637, USA
2 Division of Molecular Biology and Biochemistry, University of Missouri-Kansas City 5007 Rockhill Road, Kansas City, MO 64110, USA
3 Department of Anthropology, University of Chicago 920 East 58th Street, Chicago, IL 60637, USA

*To whom correspondence should be addressed.

Motivation: The abundance of nucleotide sequence information available has expanded horizons of inquiry for molecular evolution; however, the full potential of whole-genome analysis has not been realized because of inadequate tools. Here, we present one of the first toolkits to aid multidisciplinary high-throughput analysis.

Summary: SPEED was created to integrate molecular evolutionary data with existing genetic resources and provide a straightforward user interface to 17 352 orthologous gene groups, containing representatives from eight mammalian species and an avian outgroup.

Availability: See http://bioinfobase.umkc.edu/speed/ for access

Contact: wyckoffg{at}umkc.edu

Supplementary information: A larger version of the data model and a site map are available online.

Received on June 1, 2006; revised on August 29, 2006; accepted on August 31, 2006

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