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Bioinformatics Advance Access originally published online on October 4, 2006
Bioinformatics 2006 22(23):2940-2944; doi:10.1093/bioinformatics/btl509
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

CREMOFAC—a database of chromatin remodeling factors

Agrawal Shipra 1,{dagger}, Kumar Chetan 1 and M. R. S. Rao 1,2,*

1 Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Jakkur, Bangalore 560064, India
2 Department of Biochemistry, Indian Institute of Science Bangalore 560012, India

*To whom correspondence should be addressed.

Motivation: Chromatin-remodeling is an important event in the eukaryotic nucleus rendering nucleosomal DNA accessible for various transaction processes. Remodeling Factors facilitate the dynamic nature of chromatin through participation of the collective action of (i) ATP and (ii) Non-ATP dependent factors. Considering the importance of these factors in eukaryotes, we have developed, CREMOFAC, a dedicated and frequently updated web-database for chromatin-remodeling factors.

Results: The database harbors factors from 49 different organisms reported in literature and facilitates a comprehensive search for them. In addition, it also provides in-depth information for the factors reported in the three widely studied mammals namely, human, mouse and rat. Further, information on literature, pathways and phylogenetic relationships has also been covered. The development of CREMOFAC as a central repository for chromatin-remodeling factors and the absence of such a pre-existing database heighten its utility thus making its presence indispensable.

Availability: http://www.jncasr.ac.in/cremofac/

Contact: mrsrao{at}jncasr.ac.in

Received on July 20, 2006; revised on September 13, 2006; accepted on September 29, 2006

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