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Bioinformatics Advance Access originally published online on November 22, 2005
Bioinformatics 2006 22(3):381-383; doi:10.1093/bioinformatics/bti794
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* The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

REDfly: a Regulatory Element Database for Drosophila

Steven M. Gallo 1, Long Li 2, Zihua Hu 1 and Marc S. Halfon 2,3,*

1Center for Computational Research 140 Farber Hall, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
2Department of Biochemistry 140 Farber Hall, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
3Center of Excellence in Bioinformatics and the Life Sciences 140 Farber Hall, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA

*To whom correspondence should be addressed.

Summary: Bioinformatics studies of transcriptional regulation in the metazoa are significantly hindered by the absence of readily available data on large numbers of transcriptional cis-regulatory modules (CRMs). Even the richly annotated Drosophila melanogaster genome lacks extensive CRM information. We therefore present here a database of Drosophila CRMs curated from the literature complete with both DNA sequence and a searchable description of the gene expression pattern regulated by each CRM. This resource should greatly facilitate the development of computational approaches to CRM discovery as well as bioinformatics analyses of regulatory sequence properties and evolution.

Availability: http://redfly.ccr.buffalo.edu

Contact: mshalfon{at}buffalo.edu

Received on September 29, 2005; revised on November 17, 2005; accepted on November 17, 2005

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