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Bioinformatics Advance Access originally published online on January 10, 2006
Bioinformatics 2006 22(6):671-675; doi:10.1093/bioinformatics/btk043
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Haloferax volcanii PitA: an example of functional interaction between the Pfam chlorite dismutase and antibiotic biosynthesis monooxygenase families?

Elizabeta Bab-Dinitz 1, Hagay Shmuely 1, Julie Maupin-Furlow 2, Jerry Eichler 1 and Boaz Shaanan 1,*

1Department of Life Sciences, Ben Gurion University Beersheva 84105, Israel
2Department of Microbiology and Cell Science, University of Florida Gainesville, FL 32611-0700, USA

*To whom correspondence should be addressed.

A curious fusion between chlorite dismutase-like and antibiotic biosynthesis monooxygenase-like domains within a single open reading frame has been revealed by both sequence homology and structural modeling in Haloferax volcanii PitA and its homologues in other halophilic archaea. While this fusion may reflect an environmental adaptation to life in hypersaline environments and hence one specific to haloarchaea, PitA and its homologues may represent a paradigm of biologically-relevant interplay between these two distinct activities in accordance with the Rosetta Stone approach.

Contact: bshaanan{at}bgu.ac.il


Received on December 11, 2005; revised on January 4, 2006; accepted on January 4, 2006

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