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Bioinformatics Advance Access originally published online on January 28, 2006
Bioinformatics 2006 22(8):1027-1028; doi:10.1093/bioinformatics/btl026
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

siRecords: an extensive database of mammalian siRNAs with efficacy ratings

Yongliang Ren {dagger}, Wuming Gong {dagger}, Qiqi Xu , Xin Zheng , Dong Lin , Yejun Wang and Tongbin Li *

Department of Neuroscience, University of Minnesota Minneapolis, MN 55455, USA

*To whom correspondence should be addressed.

Summary: Short interfering RNAs (siRNAs) have been gaining popularity as the gene knock-down tool of choice by many researchers because of the clean nature of their workings as well as the technical simplicity and cost efficiency in their applications. We have constructed siRecords, a database of siRNAs experimentally tested by researchers with consistent efficacy ratings. This database will help siRNA researchers develop more reliable siRNA design rules; in the mean time, siRecords will benefit experimental researchers directly by providing them with information about the siRNAs that have been experimentally tested against the genes of their interest. Currently, more than 4100 carefully annotated siRNA sequences obtained from more than 1200 published siRNA studies are hosted in siRecords. This database will continue to expand as more experimentally tested siRNAs are published.

Availability: The siRecords database can be accessed at http://siRecords.umn.edu/siRecords/

Contact: toli{at}biocompute.umn.edu

Received on September 12, 2005; revised on January 24, 2006; accepted on January 24, 2006

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