Bioinformatics Advance Access originally published online on February 15, 2006
Bioinformatics 2006 22(8):997-998; doi:10.1093/bioinformatics/btl050
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The DIMA web resource—exploring the protein domain network
,*
1 Department of Genome Oriented Bioinformatics, Technical University of Munich Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany
2 Institute for Bioinformatics/MIPS, GSF, Research Center for Environment and Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany
*To whom correspondence should be addressed.
Summary: Conserved domains represent essential building blocks of most known proteins. Owing to their role as modular components carrying out specific functions they form a network based both on functional relations and direct physical interactions. We have previously shown that domain interaction networks provide substantially novel information with respect to networks built on full-length protein chains. In this work we present a comprehensive web resource for exploring the Domain Interaction MAp (DIMA), interactively. The tool aims at integration of multiple data sources and prediction techniques, two of which have been implemented so far: domain phylogenetic profiling and experimentally demonstrated domain contacts from known three-dimensional structures. A powerful yet simple user interface enables the user to compute, visualize, navigate and download domain networks based on specific search criteria.
Availability: http://mips.gsf.de/genre/proj/dima
Contact: p.pagel{at}gsf.de
Received on November 10, 2005; revised on January 16, 2006; accepted on February 7, 2006
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