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Bioinformatics Advance Access originally published online on October 26, 2006
Bioinformatics 2007 23(1):92-98; doi:10.1093/bioinformatics/btl554
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Recovering metabolic pathways via optimization

John E. Beasley 1,* and Francisco J. Planes 1,2

1 Mathematical Sciences, Brunel University Uxbridge, UB8 3PH, UK
2 CEIT and TECNUN, University of Navarra Manuel de Lardizabal 15, 20018 San Sebastian, Spain

To whom correspondence should be addressed.

Motivation: A metabolic pathway is a coherent set of enzyme catalysed biochemical reactions by which a living organism transforms an initial (source) compound into a final (target) compound. Some of the different metabolic pathways adopted within organisms have been experimentally determined. In this paper, we show that a number of experimentally determined metabolic pathways can be recovered by a mathematical optimization model.

Contact: john.beasley{at}brunel.ac.uk

Received on June 6, 2006; revised on September 7, 2006; accepted on October 20, 2006

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