Bioinformatics Advance Access originally published online on April 26, 2007
Bioinformatics 2007 23(13):1710-1712; doi:10.1093/bioinformatics/btm139
DITOP: drug-induced toxicity related protein database
1Key Laboratory for Cell Biology & Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences, 2The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, FuJian, P.R. China and 3Bioinformatics and Drug Design Group, Department of Computational Sciences & Pharmacy, National University of Singapore, Singapore, 117543
*To whom correspondence should be addressed.
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Abstract |
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Motivation: Drug-induced toxicity related proteins (DITRPs) are proteins that mediate adverse drug reactions (ADRs) or toxicities through their binding to drugs or reactive metabolites. Collection of these proteins facilitates better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery. Drug-induced toxicity related protein database (DITOP) is such a database that is intending to provide comprehensive information of DITRPs. Currently, DITOP contains 1501 records, covering 618 distinct literature-reported DITRPs, 529 drugs/ligands and 418 distinct toxicity terms. These proteins were confirmed experimentally to interact with drugs or their reactive metabolites, thus directly or indirectly cause adverse effects or toxicities. Five major types of drug-induced toxicities or ADRs are included in DITOP, which are the idiosyncratic adverse drug reactions, the dose-dependent toxicities, the drug–drug interactions, the immune-mediated adverse drug effects (IMADEs) and the toxicities caused by genetic susceptibility. Molecular mechanisms underlying the toxicity and cross-links to related resources are also provided while available. Moreover, a series of user-friendly interfaces were designed for flexible retrieval of DITRPs-related information. The DITOP can be accessed freely at http://bioinf.xmu.edu.cn/databases/ADR/index.html
Contact: zhiliang.ji{at}gmail.com or appo{at}bioinf.xmu.edu.cn
Supplementary information: Supplementary data are available at Bioinformatics online.
Associate Editor: Alex Bateman
The authors wish it to be know that, in their opinion, the second and third authors should be regarded as joint Second Authors.
Received on January 19, 2007; revised on March 9, 2007; accepted on April 4, 2007
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