Bioinformatics Advance Access originally published online on August 20, 2007
Bioinformatics 2007 23(18):2491-2492; doi:10.1093/bioinformatics/btm356
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Con-Struct Map: a comparative contact map analysis tool

1Department of Chemistry and Biochemistry, 2Skaggs School of Pharmacy and Pharmaceutical Sciences and 3San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
*To whom correspondence should be addressed.
| Abstract |
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Summary: Con-Struct Map is a graphical tool for the comparative study of protein structures. The tool detects potential conserved residue contacts shared by multiple protein structures by superimposing their contact maps according to a multiple structure alignment. In general, Con-Struct Map allows the study of structural changes resulting from, e.g. sequence substitutions, or alternatively, the study of conserved components of a structure framework across structurally aligned proteins. Specific applications include the study of sequence-structure relationship in distantly related proteins and the comparisons of wild type and mutant proteins.
Availability: http://pdbrs3.sdsc.edu/ConStructMap/viewer_argument_generator/singleArguments
Contact: bourne{at}sdsc.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Associate Editor: Alfonso Valencia
Present address: Razavi-Newman Center for Bioinformatics, The Salk Institute for Biological Studies, 10010 Northy Torrey Pines Road, La Jolla, CA 92037, USA.
Received on May 11, 2007; revised on July 1, 2007; accepted on July 3, 2007
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