Skip Navigation


Bioinformatics Advance Access originally published online on April 23, 2008
Bioinformatics 2008 24(12):1469-1470; doi:10.1093/bioinformatics/btn202
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (Print PDF) Freely available
Right arrowOA All Versions of this Article:
24/12/1469    most recent
btn202v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Tusnády, G. E.
Right arrow Articles by Simon, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tusnády, G. E.
Right arrow Articles by Simon, I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

TOPDOM: database of domains and motifs with conservative location in transmembrane proteins

Gábor E. Tusnády *,{dagger}, Lajos Kalmár *,{dagger}, Hédi Hegyi , Péter Tompa and István Simon

Institue of Enzymology, BRC, Hungarian Academy of Sciences, H-1113 Karolina út 29, Budapest, Hungary

*To whom correspondence should be addressed.


  Abstract

Summary: The TOPDOM database is a collection of domains and sequence motifs located consistently on the same side of the membrane in {alpha}-helical transmembrane proteins. The database was created by scanning well-annotated transmembrane protein sequences in the UniProt database by specific domain or motif detecting algorithms. The identified domains or motifs were added to the database if they were uniformly annotated on the same side of the membrane of the various proteins in the UniProt database. The information about the location of the collected domains and motifs can be incorporated into constrained topology prediction algorithms, like HMMTOP, increasing the prediction accuracy.

Availability: The TOPDOM database and the constrained HMMTOP prediction server are available on the page http://topdom.enzim.hu

Contact: tusi{at}enzim.hu; lkalmar{at}enzim.hu

Associate Editor: Burkhard Rost

{dagger}The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First authors.

Received on March 21, 2008; revised on April 14, 2008; accepted on April 21, 2008

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.