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Bioinformatics Advance Access originally published online on April 25, 2008
Bioinformatics 2008 24(12):1471-1472; doi:10.1093/bioinformatics/btn206
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

gpDB: a database of GPCRs, G-proteins, effectors and their interactions

Margarita C. Theodoropoulou 1, Pantelis G. Bagos 1,2, Ioannis C. Spyropoulos 1 and Stavros J. Hamodrakas 1,*

1Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens 157 01 and 2Department of Informatics with Applications in Biomedicine, University of Central Greece, Lamia 35 100, Greece

*To whom correspondence should be addressed.


  Abstract

Summary: gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. The sequences are classified according to a hierarchy of different classes, families and subfamilies based on literature search. The main innovation besides the classification of G-proteins, GPCRs and effectors is the relational model of the database, describing the known coupling specificity of GPCRs to their respective alpha subunits of G-proteins, and also the specific interaction between G-proteins and their effectors, a unique feature not available in any other database.

Availability: http://bioinformatics.biol.uoa.gr/gpDB

Contact: shamodr{at}biol.uoa.gr

Supplementary information: Supplementary data are available at Bioinformatics online.

Associate Editor: Jonathan Wren

Received on December 26, 2007; revised on March 26, 2008; accepted on April 23, 2008

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