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Bioinformatics 2008 24(13):i330-i338; doi:10.1093/bioinformatics/btn160
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Assessing the functional structure of genomic data

C. Huttenhower 1,2 and O.G. Troyanskaya 1,2,*

1Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08540 and 2Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA

*To whom correspondence should be addressed.


  Abstract

Motivation: The availability of genome-scale data has enabled an abundance of novel analysis techniques for investigating a variety of systems-level biological relationships. As thousands of such datasets become available, they provide an opportunity to study high-level associations between cellular pathways and processes. This also allows the exploration of shared functional enrichments between diverse biological datasets, and it serves to direct experimenters to areas of low data coverage or with high probability of new discoveries.

Results: We analyze the functional structure of Saccharomyces cerevisiae datasets from over 950 publications in the context of over 140 biological processes. This includes a coverage analysis of biological processes given current high-throughput data, a data-driven map of associations between processes, and a measure of similar functional activity between genome-scale datasets. This uncovers subtle gene expression similarities in three otherwise disparate microarray datasets due to a shared strain background. We also provide several means of predicting areas of yeast biology likely to benefit from additional high-throughput experimental screens.

Availability: Predictions are provided in supplementary tables; software and additional data are available from the authors by request.

Contact: ogt{at}princeton.edu

Supplementary information: Supplementary data are available at Bioinformatics online.


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 Genome ResHome page
C. Huttenhower, E. M. Haley, M. A. Hibbs, V. Dumeaux, D. R. Barrett, H. A. Coller, and O. G. Troyanskaya
Exploring the human genome with functional maps
Genome Res., June 1, 2009; 19(6): 1093 - 1106.
[Abstract] [Full Text] [PDF]


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