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Bioinformatics Advance Access originally published online on August 14, 2008
Bioinformatics 2008 24(20):2277-2280; doi:10.1093/bioinformatics/btn431
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes

Antonina Andreeva * and Henning Tidow

MRC Centre for Protein Engineering, Cambridge CB2 0QH, UK

*To whom correspondence should be addressed.


  Abstract

Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.

Contact: tony{at}mrc-lmb.cam.ac.uk

Supplementary information: Supplementary data are available on Bioinformatics online.

Associate Editor: Ivo Hofacker

Received on May 21, 2008; revised on August 12, 2008; accepted on August 13, 2008

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