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Bioinformatics Advance Access originally published online on August 12, 2008
Bioinformatics 2008 24(20):2412-2413; doi:10.1093/bioinformatics/btn427
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

MPSQ: a web tool for protein-state searching

Siyuan Zheng 1,2, Jia Sheng 3, Chuan Wang 1, Xiaojing Wang 1, Yao Yu 1, Yun Li 1, Alex Michie 2, Jianliang Dai 2,4, Yang Zhong 4, Pei Hao 1,2,4,*, Lei Liu 1,2,* and Yixue Li 1,2,3,*

1Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 2SCBIT-Inforsense Joint Lab, Shanghai Center for Bioinformation Technology, 100 Qinzhou Road, Shanghai 200235, 3Life Science and Technology College of Shanghai Jiao Tong University, Shanghai and 4School of Life Sciences, Fudan University, Shanghai 200433, China

*To whom correspondence should be addressed.


  Abstract

Summary: MPSQ (multi-protein-states query) is a web-based tool for the discovery of protein states (e.g. biological interactions, covalent modifications, cellular localizations). In particular, large sets of genes can be used to search for enriched state transition network maps (NMs) and features facilitating the interpretation of genomic-scale experiments such as microarrays. One NM collects all the catalogued states of a protein as well as the mutual transitions between the states. For the returned NM, graph visualization is provided for easy understanding and to guide further analysis.

Availability: MPSQ is freely available via the web at http://mpsq.biosino.org/.

Contact: phao{at}sibs.ac.cn; liulei{at}scbit.org; yxli{at}sibs.ac.cn

Associate Editor: Jonathan Wren

Received on May 22, 2008; revised on July 13, 2008; accepted on August 12, 2008

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