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Bioinformatics Advance Access originally published online on August 19, 2008
Bioinformatics 2008 24(20):2416-2417; doi:10.1093/bioinformatics/btn439
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

ITFP: an integrated platform of mammalian transcription factors

Guangyong Zheng 1,2,3, Kang Tu 3,4, Qing Yang 2, Yun Xiong 2, Chaochun Wei 5,6, Lu Xie 6, Yangyong Zhu 2,6,* and Yixue Li 3,6,*

1School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China

*To whom correspondence should be addressed.


  Abstract

Summary: Investigation of transcription factors (TFs) and their downstream regulated genes (targets) is a significant issue in post-genome era, which can provide a brand new vision for some vital biological process. However, information of TFs and their targets in mammalian is far from sufficient. Here, we developed an integrated TF platform (ITFP), which included abundant TFs and their targets of mammalian. In current release, ITFP includes 4105 putative TFs and 69 496 potential TF-target pairs for human, 3134 putative TFs and 37 040 potential TF-target pairs for mouse, and 1114 putative TFs and 18 055 potential TF-target pairs for rat. In short, ITFP will serve as an important resource for the research community of transcription and provide strong support for regulatory network study.

Availability: ITFP can be accessed at http://itfp.biosino.org/itfp

Contact: yyzhu{at}fudan.edu.cn; yxli{at}sibs.ac.cn

Associate Editor: Dmitrij Frishman

Received on May 10, 2008; revised on July 10, 2008; accepted on August 17, 2008

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