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Bioinformatics Advance Access originally published online on January 18, 2008
Bioinformatics 2008 24(4):458-461; doi:10.1093/bioinformatics/btn007
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Published by Oxford University Press (2008)

BEN: a novel domain in chromatin factors and DNA viral proteins

Saraswathi Abhiman , Lakshminarayan M. Iyer and L. Aravind *

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

*To whom correspondence should be addressed.


  Abstract

We report a previously uncharacterized {alpha}-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein–DNA and protein–protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or transcription.

Contact: aravind{at}ncbi.nlm.nih.gov

Supplementary information: Supplementary data for this study can also be accessed at http://www.ncbi.nlm.nih.gov/CBBresearch/Lakshmin/BEN/

Associate Editor: Alex Bateman

Received on November 20, 2007; revised on November 20, 2007; accepted on January 3, 2008

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