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Bioinformatics Advance Access originally published online on January 2, 2008
Bioinformatics 2008 24(4):594-596; doi:10.1093/bioinformatics/btm630
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

NetworkBLAST: comparative analysis of protein networks

Maxim Kalaev 1,*, Mike Smoot 2, Trey Ideker 2 and Roded Sharan 1,*

1School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel and 2Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA

*To whom correspondence should be addressed.


  Abstract

Summary: The identification of protein complexes is a fundamental challenge in interpreting protein–protein interaction data. Cross-species analysis allows coping with the high levels of noise that are typical to these data. The NetworkBLAST web-server provides a platform for identifying protein complexes in protein-protein interaction networks. It can analyze a single network or two networks from different species. In the latter case, NetworkBLAST outputs a set of putative complexes that are evolutionarily conserved across the two networks.

Availability: NetworkBLAST is available as web-server at: www.cs.tau.ac.il/~roded/networkblast.htm

Contact: kalaevma{at}post.tau.ac.il; roded{at}post.tau.ac.il

Associate Editor: Limsoon Wong

Received on July 22, 2007; revised on October 29, 2007; accepted on December 18, 2007

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[Abstract] [PDF]


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