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Bioinformatics Advance Access originally published online on February 21, 2008
Bioinformatics 2008 24(7):1026-1028; doi:10.1093/bioinformatics/btn068
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

GOTreePlus: an interactive gene ontology browser

Bongshin Lee 1, Kristy Brown 2, Yetrib Hathout 2 and Jinwook Seo 2,*

1Microsoft Research, One Microsoft Way, Redmond, WA 98052 and 2Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010, USA

*To whom correspondence should be addressed.


  Abstract

Summary: We developed an interactive gene ontology (GO) browser named GOTreePlus that superimposes annotation information over GO structures. It can facilitate the identification of important GO terms through interactive visualization of them in the GO structure. The interactive pie chart summarizing an annotation distribution for a selected GO term provides users with a succinct context-sensitive overview of their experimental results. We tested our GOTreePlus using a proteome profiling dataset obtained on differentiation of retinal pigment epithelial cells where 399 proteins were quantified.

Availability: http://bioinformatics.cnmcresearch.org/GOTreePlus/

Contact: jseo{at}cnmcresearch.org

Associate Editor: John Quackenbush

Received on December 13, 2007; revised on January 13, 2008; accepted on February 17, 2008

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[Abstract] [Full Text] [PDF]


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