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Bioinformatics Advance Access originally published online on November 9, 2008
Bioinformatics 2009 25(1):134-136; doi:10.1093/bioinformatics/btn581
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Genetic association analysis with FAMHAP: a major program update

Christine Herold * and Tim Becker *

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany

*To whom correspondence should be addressed.


  Abstract

Summary: FAMHAP is an established software for haplotype association analysis of nuclear families. We have released a major update that comprises various new features for case-control data. Furthermore, weprovide an additional program runFamhap that allows users to start the same method repeatedly for varying sets of genetic markers. In addition, a platform-independent graphical user interface (GUI) was developed to simplify the usage of both FAMHAP and runFamhap. The runFamhap program greatly facilitates the application of FAMHAP to genome-wide association studies (GWAS) and supports flexible genome-wide haplotype analysis. As an example, we describe application to HapMap data.

Availability: The software is available at http://famhap.meb.uni-bonn.de

Contact: herold{at}imbie.meb.uni-bonn.de; becker{at}imbie.meb.uni-bonn.de

Supplementary information: Supplementary data are available at Bioinformatics online.

Associate Editor: Alex Bateman

Received on August 18, 2008; revised on October 29, 2008; accepted on November 6, 2008

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