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Bioinformatics Advance Access originally published online on April 15, 2009
Bioinformatics 2009 25(12):1554-1555; doi:10.1093/bioinformatics/btp255
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

MapView: visualization of short reads alignment on a desktop computer

Hua Bao 1,{dagger},*, Hui Guo 1,{dagger}, Jinwei Wang 2, Renchao Zhou 1, Xuemei Lu 1 and Suhua Shi 1,*

1State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275 and 2School of Manufacturing Science and Engineering, Sichuan University, Chengdu 610064, China

*To whom correspondence should be addressed.


   Abstract

Summary: We introduce a new visual analytics tool named MapView to facilitate the representation of large-scale short reads alignment data and genetic variation analysis. MapView can handle hundreds of millions of short reads on a desktop computer with limited memory. It supports a compact alignment view for both single-end and paired end short reads, multiple navigation and zoom modes and multi-thread processing. Moreover, MapView offers automated genetic variation detection. MapView has been used in our lab and by over 10 research labs worldwide.

Availability: http://evolution.sysu.edu.cn/mapview/.

Contact: baohua100{at}hotmail.com; lssssh{at}mail.sysu.edu.cn

Supplementary information: Supplementary data are available at http://evolution.sysu.edu.cn/mapview/MVF.pdf

{dagger}The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First authors.

Associate Editor: Joaquin Dopazo


Received on March 10, 2009; revised on April 8, 2009; accepted on April 8, 2009

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