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Bioinformatics Advance Access originally published online on April 15, 2009
Bioinformatics 2009 25(12):1568-1569; doi:10.1093/bioinformatics/btp258
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

ProtVirDB: a database of protozoan virulent proteins

Jayashree Ramana and Dinesh Gupta *

Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India

*To whom correspondence should be addressed.


   Abstract

Summary: ProtVirDB is a comprehensive and user-friendly web-based knowledgebase of virulent proteins belonging to protozoan species. The database will facilitate research and provide an integrated platform for comparative studies of virulent proteins in different parasitic protozoans and organize them under a unifying classification schema with functional categories. Remarkably, one-third of the protein sequences in the database showed presence of either mono- or hetero-repeats, or both concomitantly—hence reiterating the importance of repeats in parasite virulence mechanisms. A number of useful bioinformatics tools including BLAST and tools for phylogenetic analysis are integrated with the database. With the rapidly burgeoning interest in the pathogenesis mechanisms of protozoans and ongoing genome sequencing projects, we anticipate that the database will be a useful tool for the research community.

Availability: http://bioinfo.icgeb.res.in/protvirdb

Contact: dinesh{at}icgeb.res.in

Supplementary information: Supplementary data are available at Bioinformatics online

Associate Editor: Burkhard Rost


Received on February 13, 2009; revised on March 23, 2009; accepted on April 8, 2009

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