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Bioinformatics Advance Access originally published online on July 30, 2009
Bioinformatics 2009 25(19):2619-2620; doi:10.1093/bioinformatics/btp468
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

metahdep: meta-analysis of hierarchically dependent gene expression studies

John R. Stevens 1,* and Gabriel Nicholas 2

1Department of Mathematics and Statistics, Utah State University, Logan, UT 84322-3900 and 2Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53792-4675, USA

*To whom correspondence should be addressed.


  Abstract

Summary: The metahdep package contains tools for combining the results of multiple gene expression studies. Unlike previous microarray meta-analysis packages, metahdep accounts for both sampling and hierarchical dependence among studies, as well as fundamental covariate differences between studies.

Availability: http://bioconductor.org/packages/release/Software.html

Contact: john.r.stevens{at}usu.edu

Associate Editor: Trey Ideker

Received on July 2, 2009; revised on July 2, 2009; accepted on July 24, 2009

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