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Bioinformatics Advance Access originally published online on August 13, 2009
Bioinformatics 2009 25(20):2747-2749; doi:10.1093/bioinformatics/btp487
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

PopABC: a program to infer historical demographic parameters

Joao S. Lopes 1,*, David Balding 2 and Mark A. Beaumont 1

1 School of Biological Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ and 2 Department of Epidemiology and Public Health, Imperial College, St Mary's Campus, Norfolk Place, London W2 1PG, UK

* To whom correspondence should be addressed.


  Abstract

Summary: PopABC is a computer package for inferring the pattern of demographic divergence of closely related populations and species. The software performs coalescent simulation in the framework of approximate Bayesian computation (ABC). PopABC can also be used to perform Bayesian model choice to discriminate between different demographic scenarios. The program can be used either for research or for education and teaching purposes.

Availability and Implementation: Source code and binaries are freely available at http://www.reading.ac.uk/~sar05sal/software.htm. The program was implemented in C and can run on UNIX, MacOSX and Windows operating systems.

Contact: joao.lopes{at}reading.ac.uk

Supplementary information: Supplementary data are available at Bioinformatics online.

Associate Editor: Jeffrey Barrett

Received on March 17, 2009; revised on August 6, 2009; accepted on August 10, 2009

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